Drug Name

Monoket (Isosorbide-5-Mononitrate)

Drug Uses

Isosorbide Mononitrate is used to prevent angina (chest pain) caused by heart disease.

How Taken

Use Isosorbide Mononitrate as directed by your doctor.

Take Isosorbide Mononitrate by mouth with or without food.

This medication should be taken twice daily, with the doses 7 hours apart. The first dose should preferably be taken in the morning upon waking up, unless directed otherwise by your doctor.

Do not suddenly stop taking Isosorbide Mononitrate . You may have an increased risk of side effects (eg, angina attacks). If you need to stop Isosorbide Mononitrate or add a new medicine, your doctor will gradually lower your dose.

Drug Class and Mechanism

Isosorbide Mononitrate is is a nitrate vasodilator. It works by widening the blood vessels in the body. This reduces the workload of the heart and helps to relieve chest pain.

Missed Dose

If you miss a dose of Isosorbide Mononitrate, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Storage

Store Isosorbide Mononitrate at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Isosorbide Mononitrate out of the reach of children and away from pets.

Warnings/Precautions

Do not use Isosorbide Mononitrate if:

• you are allergic to any ingredient in Isosorbide Mononitrate or to other nitrate medicines;
• you are also taking a phosphodiesterase type 5 inhibitor (eg, sildenafil, tadalafil, vardenafil);
• you drink alcohol.

Contact your doctor or health care provider right away if any of these apply to you.

Important:

Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Isosorbide Mononitrate may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Do not drink alcohol while you are taking Isosorbide Mononitrate.

When you begin taking Isosorbide Mononitrate, headaches are likely to occur. Ask your doctor for instructions on ways to reduce this side effect.

Isosorbide Mononitrate should not be used to stop an attack of angina; it is intended only for prevention of an attack.

Isosorbide Mononitrate may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Isosorbide Mononitrate.

Isosorbide Mononitrate should not be used in children; safety and effectiveness in children have not been confirmed.

If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Isosorbide Mononitrate while you are pregnant. It is not known if Isosorbide Mononitrate is found in breast milk. If you are or will be breast-feeding while you use Isosorbide Mononitrate, check with your doctor. Discuss any possible risks to your baby.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

• dizziness;
• headache;
• nausea.

Seek medical attention right away if any of these severe side effects occur:

• severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue);
• changes in vision;
• fainting;
• numbness of an arm or leg;
• severe stomach pain;
• sharp or crushing chest pain;
• sudden leg pain;
• sudden, severe headache;
• sudden shortness of breath;
• vomiting.

More Information

Isosorbide Mononitrate is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.